Редактирование: AQR (раздел)

==Publications==

{{medline-entry
|title=Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28054425
|abstract=Oxygen (O  ) homeostasis is important for all aerobic animals. However, the manner by which O  sensing and homeostasis contribute to lifespan regulation is poorly understood. Here, we use the nematode Caenorhabditis elegans to address this question. We demonstrate that a loss-of-function mutation in the neuropeptide receptor gene npr-1 and a deletion mutation in the atypical soluble guanylate cyclase gcy-35 O  sensor interact synergistically to extend worm lifespan. The function of npr-1 and gcy-35 in the O  -sensing neurons [[AQR]], PQR, and URX shortens the lifespan of the worm. By contrast, the activity of the atypical soluble guanylate cyclase O  sensor gcy-33 in these neurons is crucial for lifespan extension. In addition to [[AQR]], PQR, and URX, we show that the O  -sensing neuron BAG and the interneuron RIA are also important for the lifespan lengthening. Neuropeptide processing by the proprotein convertase EGL-3 is essential for lifespan extension, suggesting that the synergistic effect of joint loss of function of gcy-35 and npr-1 is mediated through neuropeptide signal transduction. The extended lifespan is regulated by hypoxia and insulin signaling pathways, mediated by the transcription factors HIF-1 and DAF-16. Moreover, reactive oxygen species (ROS) appear to play an important function in lifespan lengthening. As HIF-1 and DAF-16 activities are modulated by ROS, we speculate that joint loss of function of gcy-35 and npr-1 extends lifespan through ROS signaling.
|mesh-terms=* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Food
* Gene Expression Regulation
* Guanylate Cyclase
* Immunity, Innate
* Interneurons
* Longevity
* Mutation
* Neuropeptides
* Neurotransmitter Agents
* Oxidation-Reduction
* Oxygen
* Paraquat
* Reactive Oxygen Species
* Receptors, Neuropeptide Y
* Signal Transduction
* Stress, Physiological
* Temperature
* Transcription, Genetic
|keywords=* 
Caenorhabditis elegans

* NPR-1
* lifespan
* oxygen sensing
* reactive oxygen species
* soluble guanylate cyclase
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334569
}}