Редактирование: ALDH3A1 (раздел)

==Publications==

{{medline-entry
|title=Hallmarks of the cancer cell of origin: Comparisons with "energetic" cancer stem cells (e-CSCs).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30760648
|abstract=Here, we discuss the expected hallmark(s) of the cancer cell of origin and how this may be related to a new tumor cell phenotype, namely "energetic" cancer stem cells (e-CSCs). e-CSCs show many features that would be characteristic of the cancer cell of origin, including the over-expression of p21-WAF (CDKN1A), a key marker of senescence. It is tempting to speculate that the cancer cell of origin and e-CSCs are closely related entities. e-CSCs possess a hybrid phenotype, sharing key hallmarks of senescence, "stemness" and cancer. e-CSCs are hyper-proliferative and have elevated mitochondrial metabolism, with an NRF2-mediated anti-oxidant response signature, including glutaredoxin (GLRX) and [[ALDH3A1]] over-expression, possibly related to their escape from senescence. Finally, in e-CSCs, [[BCAS1]] (Breast carcinoma-amplified sequence-1) protein expression was up-regulated by >100-fold. [[BCAS1]] is a candidate oncogene associated with "stemness" and aggressive oncogenic behavior, such as Tamoxifen resistance.
|mesh-terms=* Humans
* Neoplasms
* Neoplastic Stem Cells
|keywords=* anti-oxidant response
* cancer cell of origin
* cancer stem cells (CSCs)
* metabolism
* senescence
* tamoxifen resistance
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382415
}}