Редактирование: AGO1 (раздел)

==Publications==

{{medline-entry
|title=A transcriptome-wide study on the microRNA- and the Argonaute 1-enriched small RNA-mediated regulatory networks involved in plant leaf senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26206233
|abstract=Leaf senescence is an important physiological process during the plant life cycle. However, systemic studies on the impact of microRNAs (miRNAs) on the expression of senescence-associated genes ([[SAG]]s) are lacking. Besides, whether other Argonaute 1 ([[AGO1]])-enriched small RNAs (sRNAs) play regulatory roles in leaf senescence remains unclear. In this study, a total of 5,123 and 1,399 [[AGO1]]-enriched sRNAs, excluding miRNAs, were identified in Arabidopsis thaliana and rice (Oryza sativa), respectively. After retrieving [[SAG]]s from the Leaf Senescence Database, all of the [[AGO1]]-enriched sRNAs and the miRBase-registered miRNAs of these two plants were included for target identification. Supported by degradome signatures, 200 regulatory pairs involving 120 [[AGO1]]-enriched sRNAs and 40 [[SAG]]s, and 266 regulatory pairs involving 64 miRNAs and 42 [[SAG]]s were discovered in Arabidopsis. Moreover, 13 genes predicted to interact with some of the above-identified target genes at protein level were validated as regulated by 17 [[AGO1]]-enriched sRNAs and ten miRNAs in Arabidopsis. In rice, only one [[SAG]] was targeted by three [[AGO1]]-enriched sRNAs, and one [[SAG]] was targeted by miR395. However, five [[AGO1]]-enriched sRNAs were conserved between Arabidopsis and rice. Target genes conserved between the two plants were identified for three of the above five sRNAs, pointing to the conserved roles of these regulatory pairs in leaf senescence or other developmental procedures. Novel targets were discovered for three of the five [[AGO1]]-enriched sRNAs in rice, indicating species-specific functions of these sRNA-target pairs. These results could advance our understanding of the sRNA-involved molecular processes modulating leaf senescence. 
|mesh-terms=* Arabidopsis
* Arabidopsis Proteins
* Argonaute Proteins
* Base Sequence
* Gene Expression Regulation, Plant
* Gene Regulatory Networks
* MicroRNAs
* Molecular Sequence Annotation
* Molecular Sequence Data
* Oryza
* Plant Leaves
* Plant Proteins
* RNA Stability
* RNA, Messenger
* RNA, Plant
* Transcriptome
|keywords=* Argonaute 1
* leaf senescence
* microRNA
* protein interaction
* senescence associated gene
* small RNA
|full-text-url=https://sci-hub.do/10.1111/plb.12373
}}