Редактирование: ADAMTS18 (раздел)

==Publications==

{{medline-entry
|title=A genome-wide search for genetic influences and biological pathways related to the brain's white matter integrity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22425255
|abstract=A genome-wide search for genetic variants influencing the brain's white matter integrity in old age was conducted in the Lothian Birth Cohort 1936 (LBC1936). At ∼73 years of age, members of the LBC1936 underwent diffusion MRI, from which 12 white matter tracts were segmented using quantitative tractography, and tract-averaged water diffusion parameters were determined (n = 668). A global measure of white matter tract integrity, g(FA), derived from principal components analysis of tract-averaged fractional anisotropy measurements, accounted for 38.6% of the individual differences across the 12 white matter tracts. A genome-wide search was performed with g(FA) on 535 individuals with 542,050 single nucleotide polymorphisms (SNPs). No single SNP association was genome-wide significant (all p > 5 × 10(-8)). There was genome-wide suggestive evidence for two SNPs, one in [[ADAMTS18]] (p = 1.65 × 10(-6)), which is related to tumor suppression and hemostasis, and another in LOC388630 (p = 5.08 × 10(-6)), which is of unknown function. Although no gene passed correction for multiple comparisons in single gene-based testing, biological pathways analysis suggested evidence for an over-representation of neuronal transmission and cell adhesion pathways relating to g(FA).
|mesh-terms=* Aged
* Aging
* Female
* Genome, Human
* Humans
* Male
* Nerve Fibers, Myelinated
* Nerve Tissue Proteins
* Polymorphism, Single Nucleotide

|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2012.02.003
}}