Редактирование: ACTA2 (раздел)

==Publications==

{{medline-entry
|title=Tissue Taurine Depletion Induces Profibrotic Pattern of Gene Expression and Causes Aging-Related Cardiac Fibrosis in Heart in Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30270325
|abstract=Dietary taurine deficiency results in dilated cardiomyopathy in cats while in mice taurine deficiency produced by knocking out the taurine transporter (TauT) gene leads to a reduction in cardiac function with advancing age. The present study elucidated the involvement of cardiac fibrosis in the aging-dependent cardiac disorder of the TauT-knockout (TauTKO) mouse. Old (18-24-month-old) TauTKO mice, but not young (3-5-month-old) mice, exhibit cardiac fibrosis. Transcriptome microarray analysis revealed an increase in pro-fibrotic genes, such as [[S100A4]], [[ACTA2]] and CTGF, in both young and old TauTKO hearts. Based on transcriptome-pathway analysis the genes involved in "organization of extracellular matrix," such as [[LGALS3]], are enriched in old TauTKO hearts compared to old wild-type hearts, suggesting the contribution of these genes to fibrosis. In conclusion, taurine depletion predisposes the heart to fibrosis, which leads to cardiac fibrosis upon aging.
|mesh-terms=* Actins
* Aging
* Animals
* Connective Tissue Growth Factor
* Fibrosis
* Galectin 3
* Gene Expression
* Heart
* Heart Diseases
* Mice, Knockout
* Myocardium
* S100 Calcium-Binding Protein A4
* Taurine
* Transcriptome
|keywords=* cardiac fibrosis
* cardiomyopathy
* knockout mouse
* taurine depletion
|full-text-url=https://sci-hub.do/10.1248/bpb.b18-00217
}}