Редактирование: ABI3BP (раздел)

==Publications==

{{medline-entry
|title=Long noncoding RNA MALAT1 potentiates growth and inhibits senescence by antagonizing [[ABI3BP]] in gallbladder cancer cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31174563
|abstract=Gallbladder cancer (GBC) is the most malignant cancer occurring in the biliary tract cancer featured with undesirable prognosis, in which most patients die within a year of cholecystectomy. Long noncoding RNAs (lncRNAs) function as critical regulators of multiple stages of cancers. Herein, the mechanism of lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in GBC is investigated. Microarray-based analysis initially provided data suggesting that the expression of MALAT1 was up-regulated while that of the ABI family member 3 binding protein ([[ABI3BP]]) was down-regulated in GBC tissues and cell lines. Kaplan-Meier method was then adopted to analyze the relationship between the MALAT1 expression and overall survival and disease-free survival of patients with GBC. A set of in vitro and in vivo experiments were conducted by transducing [[ABI3BP]]-vector or sh-MALAT1 into GBC cells. The results confirmed that the cancer prevention effects triggered by restored [[ABI3BP]] and depleted MALAT1 as evidenced by suppressed cell growth and enhanced cell senescence. MALAT1 was observed to down-regulate [[ABI3BP]] expression through recruitment of the enhancer of zeste homolog 2 ([[EZH2]]) to the [[ABI3BP]] promoter region while the silencing of MALAT1 or suppression of H3K27 methylation was observed to promote the expression of [[ABI3BP]]. Furthermore, GBC patients with high expression of MALAT1 indicated poor prognosis. The current study clarifies that MALAT1 silencing and [[ABI3BP]] elevation impede the GBC development through the H3K27 methylation suppression induced by [[EZH2]], highlighting a promising competitive paradigm for therapeutic approaches of GBC.
|mesh-terms=* Adult
* Animals
* Carrier Proteins
* Cell Line, Tumor
* Cell Movement
* Cell Proliferation
* Cell Transformation, Neoplastic
* Cellular Senescence
* Disease Models, Animal
* Female
* Gallbladder Neoplasms
* Gene Expression Regulation, Neoplastic
* Heterografts
* Histones
* Humans
* Male
* Methylation
* Mice
* Middle Aged
* Models, Biological
* Prognosis
* RNA Interference
* RNA, Long Noncoding
* Young Adult
|keywords=* ABI family member 3 binding protein
* Enhancer of zeste homolog 2
* Gallbladder cancer
* Growth
* Histone
* Metastasis associated lung adenocarcinoma transcript 1
* Methylation
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555920
}}