Редактирование: ABCC5 (раздел)

==Publications==

{{medline-entry
|title=Bruch membrane aging alters the gene expression profile of human retinal pigment epithelium.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16500769
|abstract=We investigated the effects of age-related changes within the Bruch membrane on the gene expression profile of the [[RPE]]. Immortalized human A[[RPE]]-19 cells were seeded onto acellular human Bruch membrane from younger and older donors and harvested 72 hr later; total RNA was isolated and the gene expression profile was determined using the Affymetrix Human Genome U95A gene chip. Twelve genes were upregulated and 8 genes were downregulated with Bruch membrane aging; RT-PCR confirms that Bruch membrane aging upregulates genes in [[RPE]] cells encoding for transforming growth factor alpha and downregulates genes for vitronectin and the membrane transporter [[ABCC5]]. The role of these changes in the pathogenesis of age-related diseases such as macular degeneration remains to be elucidated.
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Bruch Membrane
* Cell Line
* Eye Proteins
* Female
* Gene Expression
* Gene Expression Profiling
* Humans
* Male
* Middle Aged
* Oligonucleotide Array Sequence Analysis
* Pigment Epithelium of Eye
* RNA
* RNA, Messenger
* Reverse Transcriptase Polymerase Chain Reaction
* Up-Regulation

|full-text-url=https://sci-hub.do/10.1080/02713680500514628
}}