Редактирование: UVRAG

UV radiation resistance-associated gene protein (p63)

==Publications==

{{medline-entry
|title=Essential role for [[UVRAG]] in autophagy and maintenance of cardiac function.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24081163
|abstract=Ultraviolet irradiation resistance-associated gene ([[UVRAG]]) is a tumour suppressor candidate that regulates cell autophagy and endocytosis. However, the in vivo function of [[UVRAG]] remains poorly understood. We sought to determine the physiological role of [[UVRAG]] in the heart. We characterized mice with disruption of the [[UVRAG]] gene by piggyBac (PB) transposon insertion. PB construct was inserted into intron 14 of the [[UVRAG]] gene and disruption of [[UVRAG]] transcript was confirmed by reverse transcript-polymerase chain reaction. Immunoblotting revealed that [[UVRAG]] was deficient in multiple tissues. Autophagic flux was attenuated in [[UVRAG]]-deficient ([[UVRAG]](PB/PB)) mouse embryonic fibroblasts. In [[UVRAG]]-deficient hearts, autophagosomes were accumulated and autophagic flux, assessed as the increased protein abundance of LC3 II in chloroquine-treated animals, was impaired. [[UVRAG]]-deficient mice were viable, fertile, and developmentally normal. However, they developed age-related cardiomyopathy associated with compromised cardiac function. In addition, inflammatory response was enhanced in [[UVRAG]]-deficient hearts. Collectively, our findings suggest that [[UVRAG]] is essential for the regulation of autophagy and maintenance of cardiac function.
|mesh-terms=* Aging
* Animals
* Autophagy
* Cardiomyopathies
* Cells, Cultured
* Female
* Heart
* Inflammation
* Male
* Mice
* Pregnancy
* Tumor Suppressor Proteins
|keywords=* Autophagosome
* Autophagy
* Cardiomyopathy
* Inflammation
* UVRAG
|full-text-url=https://sci-hub.do/10.1093/cvr/cvt223
}}