Редактирование: USP8

Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) [KIAA0055] [UBPY]

==Publications==

{{medline-entry
|title=Inhibition of the deubiquitinase [[USP8]] corrects a Drosophila [[PINK1]] model of mitochondria dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30988163
|abstract=Aberrant mitochondrial dynamics disrupts mitochondrial function and contributes to disease conditions. A targeted RNA interference screen for deubiquitinating enzymes (DUBs) affecting protein levels of multifunctional mitochondrial fusion protein Mitofusin (MFN) identified [[USP8]] prominently influencing MFN levels. Genetic and pharmacological inhibition of [[USP8]] normalized the elevated MFN protein levels observed in [[PINK1]] and Parkin-deficient models. This correlated with improved mitochondrial function, locomotor performance and life span, and prevented dopaminergic neurons loss in [i]Drosophila[/i] [[PINK1]] KO flies. We identified a novel target antagonizing pathologically elevated MFN levels, mitochondrial dysfunction, and dopaminergic neuron loss of a [i]Drosophila[/i] model of mitochondrial dysfunction.
|mesh-terms=* Animals
* Cell Line
* Dimethyl Sulfoxide
* Dopamine
* Dopaminergic Neurons
* Down-Regulation
* Drosophila
* Drosophila Proteins
* Drosophila melanogaster
* Gene Silencing
* Longevity
* Male
* Membrane Proteins
* Mitochondria
* Parkinson Disease
* Phenotype
* Protein-Serine-Threonine Kinases
* Signal Transduction
* Transfection
* Ubiquitin-Protein Ligases
* Ubiquitin-Specific Proteases

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467245
}}