Редактирование: UGT2B15

UDP-glucuronosyltransferase 2B15 precursor (EC 2.4.1.17) (UDPGT 2B15) (UGT2B15) (HLUG4) (UDP-glucuronosyltransferase 2B8) (UDPGT 2B8) (UDPGTh-3) [UGT2B8]

==Publications==

{{medline-entry
|title=The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/17698910
|abstract=Previous in vitro studies have demonstrated that the UDP glucuronosyltransferase (UGT)2B15 and [[UGT2B17]] glucuronidate androgens and their metabolites. Our objective was to determine in vivo whether the [[UGT2B15]] D85Y and the [[UGT2B17]] deletion polymorphisms predict androgen glucuronidation and body composition. Two population-based cohorts including young adult (n = 1068; age = 18.9 yr) and elderly (n = 1001; age = 75.3 yr) men were included in the study. Serum and urine levels of testosterone (T) and dihydrotestosterone (DHT) were measured by gas chromatography-mass spectrometry, and serum levels of the major glucuronidated androgen metabolites androstane-3alpha,17beta-diol(androstanediol)-3-glucuronide, androstanediol-17-glucuronide, and androsterone-glucuronide were measured by liquid chromatography-tandem mass spectrometry. Body composition was measured by dual-energy x-ray absorptiometry. Both the [[UGT2B15]] D85Y and the [[UGT2B17]] deletion polymorphisms were associated with serum levels of androstanediol-17-glucuronide (P < 0.001) but not with levels of androstanediol-3-glucuronide or androsterone-glucuronide in both cohorts. Glucuronidation of T and DHT was associated with the [[UGT2B17]] deletion but not with the [[UGT2B15]] D85Y polymorphism, suggested by strong associations between the deletion polymorphism and urine levels of these two hormones. Both polymorphisms were associated with several different measures of fat mass (P < 0.01). The [[UGT2B17]] deletion polymorphism was associated with insulin sensitivity (P < 0.05) as indicated by the homeostasis model assessment index. The [[UGT2B15]] D85Y and the [[UGT2B17]] deletion polymorphisms are both predictors of the glucuronidation pattern of androgens/androgen metabolites. Our findings indicate that [[UGT2B17]] is involved in 17-glucuronidation of mainly T but also of DHT and androstanediol and that [[UGT2B15]] is involved in the 17-glucuronidation of androstanediol. Furthermore, these two polymorphisms are predictors of fat mass in men.
|mesh-terms=* Absorptiometry, Photon
* Adiposity
* Adolescent
* Adult
* Aged
* Aging
* Androgens
* Blood Glucose
* Body Composition
* Gene Deletion
* Glucuronides
* Glucuronosyltransferase
* Gonadal Steroid Hormones
* Humans
* Insulin
* Insulin Resistance
* Male
* Polymorphism, Genetic
* Sex Hormone-Binding Globulin

|full-text-url=https://sci-hub.do/10.1210/jc.2007-0359
}}