Редактирование: UBQLNL

protein

==Publications==

{{medline-entry
|title=Genotype×age interaction in human transcriptional ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22871458
|abstract=Individual differences in biological ageing (i.e., the rate of physiological response to the passage of time) may be due in part to genotype-specific variation in gene action. However, the sources of heritable variation in human age-related gene expression profiles are largely unknown. We have profiled genome-wide expression in peripheral blood mononuclear cells from 1240 individuals in large families and found 4472 human autosomal transcripts, representing ~4349 genes, significantly correlated with age. We identified 623 transcripts that show genotype by age interaction in addition to a main effect of age, defining a large set of novel candidates for characterization of the mechanisms of differential biological ageing. We applied a novel SNP genotype × age interaction test to one of these candidates, the ubiquilin-like gene [[UBQLNL]], and found evidence of joint cis-association and genotype by age interaction as well as trans-genotype by age interaction for [[UBQLNL]] expression. Both [[UBQLNL]] expression levels at recruitment and cis genotype are associated with longitudinal cancer risk in our study cohort.
|mesh-terms=* Adult
* Age Factors
* Aged
* Aging
* Child
* Child, Preschool
* Female
* Follow-Up Studies
* Gene Expression Regulation
* Genome-Wide Association Study
* Genotype
* Humans
* Infant
* Infant, Newborn
* Male
* Mexican Americans
* Middle Aged
* Neoplasms
* Risk Factors
* Texas
* Transcription, Genetic

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541784
}}