Редактирование: TUB

Tubby protein homolog

==Publications==

{{medline-entry
|title=C. elegans tubby regulates life span and fat storage by two independent mechanisms.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16054097
|abstract=In C. elegans, similar to in mammals, mutations in the tubby homolog, tub-1, promote increased fat deposition. Here, we show that mutation in tub-1 also leads to life span extension dependent on daf-16/FOXO. Interestingly, function of tub-1 in fat storage is independent of daf-16. A yeast two-hybrid screen identified a novel [[TUB]]-1 interaction partner (RBG-3); a RabGTPase-activating protein. Both [[TUB]]-1 and RBG-3 localize to overlapping neurons. Importantly, RNAi of rbg-3 decreases fat deposition in tub-1 mutants but does not affect life span. We demonstrate that [[TUB]]-1 is expressed in ciliated neurons and undergoes both dendritic and ciliary transport. Additionally, tub-1 mutants are chemotaxis defective. Thus, tub-1 may regulate fat storage either by modulating transport, sensing, or responding to signals in ciliated neurons. Taken together, we define a role for tub-1 in regulation of life span and show that tub-1 regulates life span and fat storage by two independent mechanisms.
|mesh-terms=* Adipose Tissue
* Amino Acid Sequence
* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Chemotaxis
* Cilia
* Forkhead Transcription Factors
* Insulin
* Insulin-Like Growth Factor I
* Lipid Metabolism
* Longevity
* Models, Biological
* Molecular Sequence Data
* Mutation
* Neurons
* Protein Binding
* Protein Transport
* RNA Interference
* Sequence Alignment
* Transcription Factors
* rab GTP-Binding Proteins

|full-text-url=https://sci-hub.do/10.1016/j.cmet.2005.06.004
}}