Редактирование: TRIM38

ubiquitin-protein ligase TRIM38 (EC 2.3.2.27) (RING finger protein 15) (RING-type E3 ubiquitin transferase TRIM38) (Tripartite motif-containing protein 38) (Zinc finger protein RoRet) [RNF15] [RORET]

==Publications==

{{medline-entry
|title=Quantitative analysis of human tissue-specific differences in methylation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/18805397
|abstract=Tissue-specific differentially methylated regions (tDMRs) have been identified and implicated for their indispensable involvement in mammalian development and tissue differentiation. In this report, a quantitative DNA methylation analysis was performed for 13 human orthologous regions of recently confirmed mouse tDMRs by using Sequenom Mass Array, by which bisulfite-treated fragments are quantitatively detected using time of flight mass spectroscopy analysis. Eight regions were shown as tDMRs in various tissues from three independent individuals. Testis DNA samples from eight individuals were also analyzed for methylation. Interestingly, there is evidence that the DNA methylation level is divergent among individuals. DNA methylation levels of five testis-specific DMRs were significantly inversely correlated with the number of spermatocytes. However, a positive correlation was seen at tDMRs located near the [[TRIM38]] and [[CASZ1]] genes. Our results indicate that tDMRs are conserved between mouse and human and may have an important role in regulating tissue function, differentiation, and aging.
|mesh-terms=* Aging
* Animals
* Base Sequence
* Carrier Proteins
* Cell Differentiation
* Conserved Sequence
* DNA Methylation
* DNA-Binding Proteins
* Humans
* Male
* Mice
* Mice, Inbred C57BL
* Oligonucleotide Array Sequence Analysis
* Proteins
* Testis
* Tissue Distribution
* Transcription Factors
* Tripartite Motif Proteins
* Ubiquitin-Protein Ligases

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613005
}}