Редактирование: TPD52

Tumor protein D52 (Protein N8)

==Publications==

{{medline-entry
|title=A testis-specific and testis developmentally regulated tumor protein D52 ([[TPD52]])-like protein [[TPD52]]L3/hD55 interacts with [[TPD52]] family proteins.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16631610
|abstract=Tumor protein D52-like proteins ([[TPD52]]) are small coiled-coil motif bearing proteins that were first identified in breast cancer. [[TPD52]] and related proteins have been implicated in cell proliferation, apoptosis, and vesicle trafficking. To date, three human [[TPD52]] members had been identified, named hD52 ([[TPD52]]), hD53 ([[TPD52]]L1), and hD54 ([[TPD52]]L2). The most important characteristic of the protein family is a highly conserved coiled-coil motif that is required for homo- and heteromeric interaction with other [[TPD52]]-like proteins. Herein, we identified a novel [[TPD52]]-like sequence ([[TPD52]]L3, or hD55) in human testis using cDNA microarray. Sequence analysis of the deduced protein suggests that hD55 contains a coiled-coil motif and is highly conserved compared with other [[TPD52]]-like sequences. Yeast two-hybrid and GST pull-down assays revealed that hD55 interacts with hD52, hD53, hD54, and itself. cDNA microarray detection found that hD55 was expressed at 5.6-fold higher levels in adult testis than in fetal testis. Additionally, the expression profile shows that hD55 is testis-specific, indicating a potential role for hD55 in testis development and spermatogenesis.
|mesh-terms=* Aging
* Amino Acid Sequence
* Gene Expression Regulation, Developmental
* Humans
* Male
* Molecular Sequence Data
* Neoplasm Proteins
* Organ Specificity
* Protein Binding
* Protein Interaction Mapping
* Spermatogenesis
* Testis
* Tissue Distribution

|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2006.03.208
}}