Редактирование: TMPRSS11A

Transmembrane protease serine 11A (EC 3.4.21.-) (Airway trypsin-like protease 1) (Epidermal type-II transmembrane serine protease) (Esophageal cancer-susceptibility gene 1 protein) [ECRG1] [HATL1] [HESP]

==Publications==

{{medline-entry
|title=Expression and genetic loss of function analysis of the HAT/DESC cluster proteases [[TMPRSS11A]] and HAT.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21853097
|abstract=Genome mining at the turn of the millennium uncovered a new family of type II transmembrane serine proteases (TTSPs) that comprises 17 members in humans and 19 in mice. TTSPs phylogenetically belong to one of four subfamilies: matriptase, hepsin/TMPRSS, corin and HAT/DESC. Whereas a wealth of information now has been gathered as to the physiological functions of members of the hepsin/TMPRSS, matriptase, and corin subfamilies of TTSPs, comparatively little is known about the functions of the HAT/DESC subfamily of proteases. Here we perform a combined expression and functional analysis of this TTSP subfamily. We show that the five human and seven murine HAT/DESC proteases are coordinately expressed, suggesting a level of functional redundancy. We also perform a comprehensive phenotypic analysis of mice deficient in two of the most widely expressed HAT/DESC proteases, [[TMPRSS11A]] and HAT, and show that the two proteases are dispensable for development, health, and long-term survival in the absence of external challenges or additional genetic deficits. Our comprehensive expression analysis and generation of [[TMPRSS11A]]- and HAT-deficient mutant mouse strains provide a valuable resource for the scientific community for further exploration of the HAT/DESC subfamily proteases in physiological and pathological processes.
|mesh-terms=* Aging
* Amino Acid Sequence
* Animals
* Base Sequence
* Gene Expression Profiling
* Gene Expression Regulation, Enzymologic
* Growth and Development
* Health
* Humans
* Membrane Proteins
* Mice
* Molecular Sequence Data
* Multigene Family
* Organ Specificity
* RNA, Messenger
* Serine Endopeptidases
* Serine Proteases
* Survival Analysis

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154331
}}