Редактирование: SHOX2

Short stature homeobox protein 2 (Homeobox protein Og12X) (Paired-related homeobox protein SHOT) [OG12X] [SHOT]

==Publications==

{{medline-entry
|title=Role of [[SHOX2]] in the development of intervertebral disc degeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26697824
|abstract=Intervertebral disc ([[IVD]]) degeneration is the most common cause of low back pain, which affect 80% of the population during their lives, with heavy economic burden. Many factors have been demonstrated to participate in [[IVD]] degeneration. In this study, we investigated the role of short stature homeobox 2 ([[SHOX2]]) in the development of [[IVD]] degeneration. First, we detected the expression of [[SHOX2]] in different stages of human [[IVD]] degeneration; then explored the role of [[SHOX2]] on nucleus pulposus (NP) cells proliferation and apoptosis, finally we evaluated the effect of [[SHOX2]] on the production of extracellular matrix in NP cells. Results showed that the expression of [[SHOX2]] is mainly in NP compared with AF tissues, its expression decreased with the severity of human [[IVD]] degeneration. [[TNF]]-α treatment led to dose- and time-dependent decrease in [[SHOX2]] mRNA, protein expression and promoter activity in NP cells. The silencing of [[SHOX2]] inhibited NP cells proliferation and induced NP cells apoptosis. Finally, [[SHOX2]] silencing led to decreased aggrecan and collagen II expression, along with increased ECM degrading enzymes [[MMP3]] and ADAMTS-5 in NP cells. In summary, our results indicated that [[SHOX2]] plays an important role in the process of [[IVD]] degeneration, and might be a protective factor for [[IVD]] degeneration. Further studies are required to confirm its exact role, and clarify the mechanism. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1047-1057, 2017.
|mesh-terms=* Aging
* Animals
* Apoptosis
* Cell Proliferation
* Extracellular Matrix
* Homeodomain Proteins
* Intervertebral Disc Degeneration
* Nucleus Pulposus
* Primary Cell Culture
* Rats, Sprague-Dawley
* Tumor Necrosis Factor-alpha
|keywords=* SHOX2 gene
* TNF-α
* intervertebral disc degeneration
|full-text-url=https://sci-hub.do/10.1002/jor.23140
}}