Редактирование: SCAMP4

Secretory carrier-associated membrane protein 4 (Secretory carrier membrane protein 4)

==Publications==

{{medline-entry
|title=[[SCAMP4]] enhances the senescent cell secretome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29967290
|abstract=The senescence-associated secretory phenotype (SASP) is a major trait of senescent cells, but the molecular regulators of SASP factor secretion are poorly understood. Mass spectrometry analysis revealed that secretory carrier membrane protein 4 ([[SCAMP4]]) levels were strikingly elevated on the surface of senescent cells compared with proliferating cells. Interestingly, silencing [[SCAMP4]] in senescent fibroblasts reduced the secretion of SASP factors, including interleukin 6 (IL6), IL8, growth differentiation factor 15 (GDF-15), C-X-C motif chemokine ligand 1 (CXCL1), and [[IL7]], while, conversely, [[SCAMP4]] overexpression in proliferating fibroblasts increased SASP factor secretion. Our results indicate that [[SCAMP4]] accumulates on the surface of senescent cells, promotes SASP factor secretion, and critically enhances the SASP phenotype.
|mesh-terms=* Carrier Proteins
* Cell Line
* Cell Proliferation
* Cellular Senescence
* Fibroblasts
* Gene Silencing
* Humans
* Membrane Proteins
* Proteasome Endopeptidase Complex
* Ubiquitin
|keywords=* SCAMP4
* cellular senescence
* human diploid fibroblasts
* senescence-associated secretory phenotype (SASP)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075036
}}