Редактирование: RPL17

60S ribosomal protein L17 (60S ribosomal protein L23) (Large ribosomal subunit protein uL22) (PD-1)

==Publications==

{{medline-entry
|title=Sex- and age-related differences in ribosomal proteins L17 and L37, as well as androgen receptor protein, in the song control system of zebra finches.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/20933575
|abstract=The zebra finch song system is sexually dimorphic--only males sing, and the morphology of forebrain regions controlling the learning and production of this song is greatly enhanced in males compared to females. Masculinization appears to involve effects of steroid hormones as well as other factors, perhaps including the expression of sex chromosome genes (males: ZZ, females: ZW). The present study investigated three proteins--two encoded by Z-linked genes, ribosomal proteins L17 and L37 ([[RPL17]] and [[RPL37]]), including their co-localization with androgen receptor ([[AR]]), from post-hatching day 25 to adulthood. Extensive co-expression of [[AR]] with the ribosomal proteins was detected in the three song nuclei investigated (HVC, robust nucleus of the arcopallium (RA), and Area X) across these ages. In general, more cells expressed each of these proteins in males compared to females, and the sex differences increased as animals matured. Specific patterns differed across regions and between [[RPL17]] and [[RPL37]], which suggest potential roles of one or both of these proteins in the incorporation and/or differentiation of song system cells.
|mesh-terms=* Aging
* Animals
* Brain
* Cell Count
* Female
* Finches
* Male
* Neurons
* Receptors, Androgen
* Ribosomal Proteins
* Sex Characteristics
* Vocalization, Animal

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991423
}}
{{medline-entry
|title=Sexually dimorphic expression of the genes encoding ribosomal proteins L17 and L37 in the song control nuclei of juvenile zebra finches.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16938280
|abstract=Studies evaluating the role of steroid hormones in sexual differentiation of the zebra finch song system have produced complicated and at times paradoxical results, and indicate that additional factors may be critical. Therefore, in a previous study we initiated a screen for differential gene expression in the telencephalon of developing male and female zebra finches. The use of cDNA microarrays and real-time quantitative PCR revealed increased expression of the genes encoding ribosomal proteins L17 and L37 ([[RPL17]] and [[RPL37]]) in the male forebrain as a whole. Preliminary in situ hybridization data then indicated enhanced expression of both these genes in song control regions. Two experiments in the present study quantified the mRNA expression. The first utilized 25-day-old male and female zebra finches. The second compared a separate set of juveniles to adults of both sexes to both re-confirm enhanced expression in juvenile males and to determine whether it is limited to developing animals. In Experiment 1, males exhibited increased expression of both [[RPL17]] and [[RPL37]] compared to females in Area X, the robust nucleus of the arcopallium (RA), and the ventral ventricular zone (VVZ), which may provide neurons to Area X. Experiment 2 replicated the sexually dimorphic expression of these genes at post-hatching day 25, and documented that the sex differences are eliminated or greatly reduced in adults. The results are consistent with the idea that these ribosomal proteins may influence sexual differentiation of Area X and RA, potentially regulating the genesis and/or survival of neurons.
|mesh-terms=* Aging
* Animals
* Brain
* Cell Differentiation
* DNA, Complementary
* Female
* Finches
* Gene Expression Regulation, Developmental
* Male
* Neurons
* RNA, Messenger
* Ribosomal Proteins
* Sex Characteristics
* Sex Differentiation
* Sexual Behavior, Animal
* Stem Cells
* Telencephalon
* Vocalization, Animal

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878125
}}