Редактирование: PXN

Paxillin

==Publications==

{{medline-entry
|title=pxn-1 and pxn-2 May Interact Negatively during Neuronal Development and Aging in C. elegans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26194821
|abstract=C. elegans has two functional peroxidasins ([[PXN]]), [[PXN]]-1 and [[PXN]]-2. [[PXN]]-2 is essential to consolidate the extracellular matrix during development and is suggested to interact with [[PXN]]-1 antagonistically. pxn-1 is involved in neuronal development and possibly maintenance; therefore, we investigated the relationship between pxn-1 and pxn-2 in neuronal development and in aging. During neuronal development, defects caused by pxn-1 overexpression were suppressed by overexpression of both pxn-1 and pxn-2. In neuronal aging process, pxn-1 mutants showed less age-related neuronal defects, such as neuronal outgrowth, neuronal wavy processes, and enhanced short-term memory performance. In addition, pxn-2 overexpressing animals retained an intact neuronal morphology when compared with age-matched controls. Consistent with these results, overexpression of both pxn-1 and pxn-2 restored the severe neuronal defects present with pxn-1 overexpression. These results implied that there is a negative relationship between pxn-1 and pxn-2 via pxn-1 regulating pxn-2. Therefore, pxn-1 may function in neuronal development and age-related neuronal maintenance through pxn-2. 
|mesh-terms=* Aging
* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Models, Animal
* Neurogenesis
* Peroxiredoxins
|keywords=* C. elegans
* antagonistic relationship
* neuronal aging
* neuronal development
* pxn-1
* pxn-2
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546945
}}