Редактирование: PTPN3

Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) [PTPH1]

==Publications==

{{medline-entry
|title=Normal TCR signal transduction in mice that lack catalytically active [[PTPN3]] protein tyrosine phosphatase.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/17339465
|abstract=[[PTPN3]] (PTPH1) is a cytoskeletal protein tyrosine phosphatase that has been implicated as a negative regulator of early TCR signal transduction and T cell activation. To determine whether [[PTPN3]] functions as a physiological negative regulator of TCR signaling in primary T cells, we generated gene-trapped and gene-targeted mouse strains that lack expression of catalytically active [[PTPN3]]. [[PTPN3]] phosphatase-negative mice were born in expected Mendelian ratios and exhibited normal growth and development. Furthermore, numbers and ratios of T cells in primary and secondary lymphoid organs were unaffected by the [[PTPN3]] mutations and there were no signs of spontaneous T cell activation in the mutant mice with increasing age. TCR-induced signal transduction, cytokine production, and proliferation was normal in [[PTPN3]] phosphatase-negative mice. This was observed using both quiescent T cells and recently stimulated T cells where expression of [[PTPN3]] is substantially up-regulated. We conclude, therefore, that the phosphatase activity of [[PTPN3]] is dispensable for negative regulation of TCR signal transduction and T cell activation.
|mesh-terms=* Aging
* Animals
* Cell Proliferation
* Cells, Cultured
* Cytokines
* Lymphocyte Activation
* Mice
* Mice, Transgenic
* Protein Tyrosine Phosphatase, Non-Receptor Type 3
* Protein Tyrosine Phosphatases
* Receptors, Antigen, T-Cell
* Signal Transduction
* T-Lymphocytes
* Up-Regulation

|full-text-url=https://sci-hub.do/10.4049/jimmunol.178.6.3680
}}