Редактирование: PCSK2

Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2) [NEC2]

==Publications==

{{medline-entry
|title=Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21102462
|abstract=To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at [[LIN28B]] (P = 5.4 × 10⁻⁶⁰) and 9q31.2 (P = 2.2 × 10⁻³³), we identified 30 new menarche loci (all P < 5 × 10⁻⁸) and found suggestive evidence for a further 10 loci (P < 1.9 × 10⁻⁶). The new loci included four previously associated with body mass index (in or near [[FTO]], [[SEC16B]], [[TRA2B]] and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, [[CRTC1]] and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, [[PCSK2]] and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.
|mesh-terms=* Adolescent
* Aging
* Body Height
* Body Size
* Child
* DNA Copy Number Variations
* Female
* Genetic Loci
* Genetic Predisposition to Disease
* Genome-Wide Association Study
* Humans
* Inheritance Patterns
* Menarche
* Obesity
* Polymorphism, Single Nucleotide
* Quantitative Trait Loci
* Reproducibility of Results
* Time Factors

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140055
}}