Редактирование: OLIG1

Oligodendrocyte transcription factor 1 (Oligo1) (Class B basic helix-loop-helix protein 6) (bHLHb6) (Class E basic helix-loop-helix protein 21) (bHLHe21) [BHLHB6] [BHLHE21]

==Publications==

{{medline-entry
|title=Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/14989603
|abstract=Recent in situ hybridization studies showed that mRNA levels of [[OLIG1]] and [[OLIG2]] transcription factors are elevated in oligodendrogliomas. We raised polyclonal antibodies against a synthetic peptide homologous to the human transcription factor Olig1 and studied by immunohistochemistry the expression of Olig1 in 84 brain tumors and in non-neoplastic brain tissues. All oligodendrogliomas, oligoastrocytomas, and dysembryoplastic neuroepithelial tumors showed moderate to strong intranuclear immunoreactivity in cells morphologically identified as oligodendrocytes. In addition, some astrocytomas showed a slight to moderate intranuclear immunoreactivity. None of the other neuroepithelial and non-neuroepithelial tumors showed nuclear immunoreactivity. Double immunostaining of oligodendrogliomas, oligoastrocytomas, and glioblastoma multiforme (GBM) using antibodies against Olig1 and [[GFAP]] showed the presence of 3 different cell populations: 1) immunopositive for Olig1 and immunonegative for [[GFAP]], histologically identified as oligodendrocytes; 2) immunopositive only for [[GFAP]], histologically identified as astrocytes; and 3) immunonegative for both antibodies ("null cells"), histologically observed as a population of cells usually with round nuclei and a small amount of cytoplasm. The use of double immunostaining facilitated the distinction among these 3 different tumors. In summary, the use of immunohistochemistry using Olig1 antibodies alone or in combination with anti-[[GFAP]] antibody, which can be performed in the routine diagnostic setting, may help in the diagnosis of neuroepithelial tumors.
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Astrocytoma
* Basic Helix-Loop-Helix Transcription Factors
* Blotting, Western
* Brain Neoplasms
* Cell Count
* Child
* Child, Preschool
* DNA-Binding Proteins
* Ependymoma
* Glial Fibrillary Acidic Protein
* Humans
* Immunohistochemistry
* Middle Aged
* Nerve Tissue Proteins
* Oligodendroglioma

|full-text-url=https://sci-hub.do/10.1093/jnen/63.2.170
}}
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