Редактирование: NSUN2

RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4) [SAKI] [TRM4]

==Publications==

{{medline-entry
|title=RNA methyltransferase [[NSUN2]] promotes stress-induced HUVEC senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26992231
|abstract=The tRNA methyltransferase [[NSUN2]] delays replicative senescence by regulating the translation of [[CDK1]] and [[CDKN1B]] mRNAs. However, whether [[NSUN2]] influences premature cellular senescence remains untested. Here we show that [[NSUN2]] methylates SHC mRNA in vitro and in cells, thereby enhancing the translation of the three SHC proteins, p66SHC, p52SHC, and p46SHC. Our results further show that the elevation of SHC expression by [[NSUN2]]-mediated mRNA methylation increased the levels of ROS, activated p38MAPK, thereby accelerating oxidative stress- and high-glucose-induced senescence of human vascular endothelial cells (HUVEC). Our findings highlight the critical impact of [[NSUN2]]-mediated mRNA methylation in promoting premature senescence. 
|mesh-terms=* Blotting, Western
* CDC2 Protein Kinase
* Cells, Cultured
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p27
* Gene Expression Regulation
* HCT116 Cells
* Human Umbilical Vein Endothelial Cells
* Humans
* Methylation
* Methyltransferases
* Oxidative Stress
* RNA Interference
* RNA, Messenger
* Reactive Oxygen Species
* Src Homology 2 Domain-Containing, Transforming Protein 1
* p38 Mitogen-Activated Protein Kinases
|keywords=* Gerotarget
* HUVEC
* NSUN2
* SHC mRNA methylation
* premature senescence
* translational regulation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991368
}}