Редактирование: MUC4

Mucin-4 precursor (MUC-4) (Ascites sialoglycoprotein) (ASGP) (Pancreatic adenocarcinoma mucin) (Testis mucin) (Tracheobronchial mucin) [Contains: Mucin-4 alpha chain (Ascites sialoglycoprotein 1) (ASGP-1); Mucin-4 beta chain (Ascites sialoglycoprotein 2) (ASGP-2)]

==Publications==

{{medline-entry
|title=[Lacrimal gland-associated mucins. Age related production and their role in the pathophysiology of dry eye].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/15678360
|abstract=The secretory cells of the human lacrimal gland show a PAS-positive reaction in cytochemical staining procedures, suggesting the production of mucous substances. Recently, these substances were differentiated according to modern molecular classifications. Expression studies detected mRNA for [[MUC1]], [[MUC4]], [[MUC5AC]], [[MUC5B]], [[MUC6]], and [[MUC7]], whereas [[MUC2]] transcripts were absent in all samples investigated. Immunohistochemistry revealed membrane-bound [[MUC1]] at the apical surface of acinar cells, [[MUC5AC]] associated with goblet cells of excretory ducts, [[MUC5B]] and [[MUC7]] in the cytoplasm of acinar cells, and [[MUC7]] also in epithelial cells of excretory ducts. [[MUC2]] (RT-PCR negative) and [[MUC6]] (RT-PCR positive) were not detectable by immunohistochemistry. [[MUC4]] mRNA was present in all samples from patients treated for dry eye but only in 6 of 30 glands from individuals who did not receive treatment with artificial tears. Dot-blot analyses clearly revealed increased amounts of [[MUC4]], [[MUC5AC]] and [[MUC5B]] in the glands of elderly women who received treatment for dry eye as compared to the remaining samples. These results confirm that the human lacrimal gland synthesizes a spectrum of mucins, some of which might be involved in the pathophysiology of dry eye syndrome.
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Child
* Dry Eye Syndromes
* Female
* Humans
* Lacrimal Apparatus
* Male
* Middle Aged
* Mucins
* Tissue Distribution

|full-text-url=https://sci-hub.do/10.1007/s00347-004-1075-4
}}
{{medline-entry
|title=Expression and localization of Muc4/sialomucin complex (SMC) in the adult and developing rat intestine: implications for Muc4/SMC function.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/15389518
|abstract=Muc4/sialomucin complex (SMC) is a high molecular mass heterodimeric membrane mucin, encoded by a single gene, and originally discovered in a highly metastatic ascites rat mammary adenocarcinoma. Subsequent studies have shown that it is a prominent component of many accessible and vulnerable epithelia, including the gastrointestinal tract. Immunoblot and immunofluorescence analyses demonstrated that Muc4/SMC expression in the rat small intestine increases from proximal to distal regions and is located predominantly in cells at the base of the crypts. These cells were postulated to be Paneth cells, based on their location, morphology, and secretory granule content. Immunohistochemistry indicated the presence of Muc4/SMC in these granules. Muc4/SMC expression was higher in the rat colon than small intestine and was abundantly present in colonic goblet cells, but not in goblet cells in the small intestine. Immunohistochemistry also suggested the presence of [[MUC4]] in human colonic goblet cells. Biochemical analyses indicated that rat colonic Muc4/SMC is primarily the soluble form of the membrane mucin. Analyses of Muc4/SMC during development of the rat gastrointestinal tract showed its appearance at embryonic day 14 of the esophagus and at day 15 at the surface of the undifferentiated stratified epithelium at the gastroduodenal junction, then later at cell surfaces in the more distal regions of the differentiated epithelium of the small intestine, culminating in expression as an intracellular form in the crypts of the small intestine at about day 21. Limited expression in the colon was observed during development before birth at cell surfaces, with expression as an intracellular form in the goblet cells arising during the second week after birth. These results suggest that membrane mucin Muc4/SMC serves different functions during development of the intestine in the rat, but is primarily a secreted product in the adult animal.
|mesh-terms=* Age Factors
* Aging
* Animals
* Cell Compartmentation
* Cell Differentiation
* Colon
* Duodenum
* Esophagus
* Female
* Goblet Cells
* Humans
* Intestinal Mucosa
* Intestine, Small
* Mucin-4
* Mucins
* Paneth Cells
* Rats
* Rats, Inbred F344
* Secretory Vesicles
* Species Specificity

|full-text-url=https://sci-hub.do/10.1002/jcp.20121
}}