Редактирование: MTA3

Metastasis-associated protein MTA3 [KIAA1266]

==Publications==

{{medline-entry
|title=[[CHD5]], a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21931736
|abstract=[[CHD5]] is frequently deleted in neuroblastoma and is a tumor suppressor gene. However, little is known about the role of [[CHD5]] other than it is homologous to chromatin remodeling ATPases. We found [[CHD5]] mRNA was restricted to the brain; by contrast, most remodeling ATPases were broadly expressed. [[CHD5]] protein isolated from mouse brain was associated with [[HDAC2]], p66ß, [[MTA3]] and RbAp46 in a megadalton complex. [[CHD5]] protein was detected in several rat brain regions and appeared to be enriched in neurons. [[CHD5]] protein was predominantly nuclear in primary rat neurons and brain sections. Microarray analysis revealed genes that were upregulated and downregulated when [[CHD5]] was depleted from primary neurons. [[CHD5]] depletion altered expression of neuronal genes, transcription factors, and brain-specific subunits of the SWI/SNF remodeling enzyme. Expression of gene sets linked to aging and Alzheimer's disease were strongly altered by [[CHD5]] depletion from primary neurons. Chromatin immunoprecipitation revealed [[CHD5]] bound to these genes, suggesting the regulation was direct. Together, these results indicate that [[CHD5]] protein is found in a NuRD-like multi-protein complex. [[CHD5]] expression is restricted to the brain, unlike the closely related family members [[CHD3]] and [[CHD4]]. [[CHD5]] regulates expression of neuronal genes, cell cycle genes and remodeling genes. [[CHD5]] is linked to regulation of genes implicated in aging and Alzheimer's disease.
|mesh-terms=* Aging
* Alzheimer Disease
* Animals
* Brain
* Chromatin
* Chromatin Immunoprecipitation
* DNA Helicases
* Gene Expression Profiling
* Gene Expression Regulation, Enzymologic
* Humans
* Mi-2 Nucleosome Remodeling and Deacetylase Complex
* Mice
* Multiprotein Complexes
* Neurons
* Oligonucleotide Array Sequence Analysis
* Rats
* Trans-Activators

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172237
}}