Редактирование: MT1M

Metallothionein-1M (MT-1M) (Metallothionein-IM) (MT-IM) [MT1K]

==Publications==

{{medline-entry
|title=A novel strain of Lactobacillus mucosae isolated from a Gaotian villager improves in vitro and in vivo antioxidant as well as biological properties in D-galactose-induced aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26709186
|abstract=Twelve isolates isolated from the gastrointestinal tracts of Gaotian villagers in China, who had a lifespan of 92 yr, were examined for their antioxidants using free radical scavenging activity and 2,2-diphenyl-1-picrylhydrazyl. Three strains (i.e., Lactobacillus mucosae LMU1001, and Lactobacillus plantarum LPL0902 and LPL0302) were selected as candidates to prepare yogurt for testing their antioxidants in a model of d-galactose-induced aging mice, with vitamin C as a positive control. The results showed that L. mucosae LMU1001 was the best strain, which had similar in vivo antioxidant activity as vitamin C. A significant increase was found in the activities of glutathione peroxidase in serum and total superoxide dismutase in the liver, and a decrease in the level of malondialdehyde in serum. Regarding mRNA expression level detected quantitatively by real-time PCR, we observed that L. mucosae LMU1001 significantly upregulated antioxidant genes (i.e., [[MT1A]] and [[MT1M]] in HT-29 and Caco-2) and those genes (i.e., MT1, MT2, GPx1, and GPx2) in the intestinal tract of the model mice. Hence, this strain could be considered as a potential probiotic lactic acid bacterium for improving antioxidant levels in functional foods. 
|mesh-terms=* Aged, 80 and over
* Aging
* Animals
* Antioxidants
* Caco-2 Cells
* China
* Functional Food
* Galactose
* Glutathione Peroxidase
* Humans
* Intestines
* Lactobacillus
* Lactobacillus plantarum
* Liver
* Longevity
* Malondialdehyde
* Mice
* Models, Animal
* Probiotics
* Superoxide Dismutase
|keywords=* 2,2-diphenyl-1-picrylhydrazyl
* antioxidant activity
* d-galactose-induced aging mice
* hydroxyl radical
* reducing power
|full-text-url=https://sci-hub.do/10.3168/jds.2015-10265
}}