Редактирование: MMP20

Matrix metalloproteinase-20 precursor (EC 3.4.24.-) (MMP-20) (Enamel metalloproteinase) (Enamelysin)

==Publications==

{{medline-entry
|title=Identification of the effects of aging-related gene-matrix metalloproteinase on allograft outcomes in kidney transplantation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23953525
|abstract=Aging plays a profound role in the ability of the kidney to function. Aging which varies among individuals, has been associated with the matrix metalloproteinase (MMP) 7 and 20 genes. This study was conducted to analyze correlations between polymorphisms of MMP genes [rs880197 in [[MMP7]] (A>T) and rs1711437 in [[MMP20]] (G>A)] and transplant outcomes in 235 recipients. Transplant outcomes were evaluated according to the sum of the A alleles in the recipients and the donors. The group with a high number of A alleles (≥3) was compared with the group with a low number (<3). The group with a high number of [[MMP7]] A alleles showed a lower risk of chronic tubulointerstitial lesion than the group with a low number (P = .009). The group with a high number of [[MMP20]] A alleles had showed better long-term kidney function at 10 years after transplantation than the group with a low number (P = .026). Furthermore, the group with a high number of [[MMP20]] A alleles showed a trend toward better graft survival compared with the group with a low number, especially among recipients followed for >1 year (P = .022). Polymorphisms of [[MMP7]] and [[MMP20]] genes may be surrogate markers to predict long-term outcomes after kidney transplantation.
|mesh-terms=* Adult
* Age Factors
* Aging
* Female
* Gene Frequency
* Genotype
* Graft Survival
* Humans
* Kidney Transplantation
* Male
* Matrix Metalloproteinase 20
* Matrix Metalloproteinase 7
* Middle Aged
* Phenotype
* Polymorphism, Genetic
* Risk Factors
* Time Factors
* Treatment Outcome
* Young Adult

|full-text-url=https://sci-hub.do/10.1016/j.transproceed.2013.03.020
}}