Редактирование: MC4R

Melanocortin receptor 4 (MC4-R)

==Publications==

{{medline-entry
|title=Melanocortin-4 receptor rs17782313 polymorphisms are associated with serum triglycerides in older Chinese women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26965781
|abstract=[[MC4R]] (melanocortin-4 receptor) gene polymorphisms have been associated with serum triglycerides ([[TG]]) in Caucasians and Japanese, but no reports are available Chinese. The purpose of this study was to find whether there was an association of rs17782313 polymorphisms at the [[MC4R]] gene with serum [[TG]] in elderly Chinese. 2,012 over 40 years participated in a cross-sectional study in which their body mass index (BMI), [[TG]], high density lipoprotein-cholesterol (HDL-C), and [[MC4R]] rs17782313 polymorphisms were determined. For women, carriers of the T/T genotype had significantly lower serum [[TG]] than those with C/C genotype (p=0.006). Carriers of the C/C genotype of this polymorphisms exhibited significantly lower fasting HDL-C levels compared with T/T and T/C genotypes (p=0.025), and increased glycosylated hemoglobin (HbA1c) (p=0.043), but no change in blood pressure. Higher serum [[TG]] in carriers of the C/C genotype of [[MC4R]] gene remained stable after adjustment for age, smoking, drinking, BMI, waist circumference (WC) and three or more components of the metabolic syndrome (MS) by multivariable linear regression (p=0.01) in women. The carriers of the C/C genotype of [[MC4R]] gene showed significantly greater odds ratio for [[TG]] than T/C and T/T genotypes, even when adjusted for age, smoking, drinking, BMI and WC in women. The rs17782313 C/C genotype is associated with higher [[TG]] levels in older Chinese women.
|mesh-terms=* Aged
* Aging
* Body Mass Index
* China
* Cholesterol, HDL
* Cross-Sectional Studies
* Female
* Genotype
* Glycated Hemoglobin A
* Humans
* Male
* Metabolic Syndrome
* Middle Aged
* Polymorphism, Genetic
* Receptor, Melanocortin, Type 4
* Sex Factors
* Triglycerides
* Waist Circumference

|full-text-url=https://sci-hub.do/10.6133/apjcn.2016.25.1.18
}}
{{medline-entry
|title=Polymorphic variants of neurotransmitter receptor genes may affect sexual function in aging males: data from the HALS study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23485949
|abstract=Human behavior is influenced by a number of brain neurotransmitters. Central dopamine, serotonin and melanocortin systems have special importance for male sexual function. We searched for associations between male aging symptoms and polymorphic sites of serotonin (5-[[HTR1B]]), melanocortin ([[MC4R]]) and dopamine ([[DRD2]], [[DRD4]]) receptors. In a population-based sample, genotyping of 5-[[HTR1B]] (polymorphism: G861C), [[MC4R]] (polymorphisms: C-2745T, Val103Ile), [[DRD2]] (polymorphism: C313T) and [[DRD4]] (polymorphism: 48-bp VNTR) was performed in 387 healthy men. The Aging Males' Symptoms (AMS) scale was used to evaluate specific ailments of aging men. We analyzed answers to questions from the AMS scale. Five points of the questionnaire addressed sexual symptoms of the aging male: feeling of passing one's peak, decrease in beard growth, decrease in ability/frequency to perform sexually, decrease in the number of morning erections, and decrease in sexual desire/libido (lacking pleasure in sex, lacking desire for sexual intercourse). Relations between reported symptoms and variants of the polymorphic sites of the studied genes were assessed. After adjusting for confounding factors (education, arterial hypertension, physical activity, weight, waist circumference) an association between the sexual dimension of AMS and genetic variants of 5-[[HTR1B]] G861C (p = 0.04) was observed. Variability of neurotransmitter receptor genes may be associated with sexual symptoms of aging in men.
|mesh-terms=* Adult
* Aged
* Aging
* Genetic Variation
* Humans
* Male
* Middle Aged
* Poland
* Polymorphism, Genetic
* Receptor, Serotonin, 5-HT1B
* Receptors, Neurotransmitter
* Sexual Behavior
* Statistics as Topic

|full-text-url=https://sci-hub.do/10.1159/000350324
}}