Редактирование: LMO2

Rhombotin-2 (Cysteine-rich protein TTG-2) (LIM domain only protein 2) (LMO-2) (T-cell translocation protein 2) [RBTN2] [RBTNL1] [RHOM2] [TTG2]

==Publications==

{{medline-entry
|title=Aging-dependent DNA hypermethylation and gene expression of [[GSTM1]] involved in T cell differentiation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28596482
|abstract=This study investigated whether aging was associated with epigenetic changes of DNA hypermethylation on immune gene expression and lymphocyte differentiation. We screened CG sites of methylation in blood leukocytes from different age populations, picked up genes with age-related increase of CG methylation content more than 15%, and validated immune related genes with CG hypermethylation involved in lymphocyte differentiation in the aged population. We found that 12 genes (EXHX1ã IL-10ã TSP50ã [[GSTM1]]ãSLC5A5ãSPI1ãF2Rã[[LMO2]]ãPTPN6ãFGFR2ãMMP9ãMET) were associated with promoter or exon one DNA hypermethylation in the aged group. Two immune related genes, [[GSTM1]] and [[LMO2]], were chosen to validate its aging-related CG hypermethylation in different leukocytes. We are the first to validate that [[GSTM1]]_P266 and [[LMO2]]_E128 CG methylation contents in T lymphocytes but not polymorphonuclear cells (PMNs) or mononuclear cells (MNCs) were significantly increased in the aged population. The [[GSTM1]] mRNA expression in T lymphocytes but not PMNs or MNCs was inversely associated with the [[GSTM1]] CG hypermethylation levels in the aged population studied. Further studies showed that lower [[GSTM1]] CG methylation content led to the higher [[GSTM1]] mRNA expression in T cells and knockdown of [[GSTM1]] mRNA expression decreased type 1 T helper cell (Th1) differentiation in Jurkat T cells and normal adult [[CD4]] T cells. The [[GSTM1]]_P266 hypermethylation in the aged population associated with lower [[GSTM1]] mRNA expression was involved in Th1 differentiation, highlighting that modulation of aging-associated [[GSTM1]] methylation may be able to enhance T helper cell immunity in the elders.
|mesh-terms=* Adaptor Proteins, Signal Transducing
* Aging
* Cell Differentiation
* CpG Islands
* DNA Methylation
* Epigenesis, Genetic
* Gene Expression Profiling
* Gene Expression Regulation
* Glutathione Transferase
* Humans
* LIM Domain Proteins
* Leukocytes
* Proto-Oncogene Proteins
* RNA, Messenger
* T-Lymphocytes
|keywords=* DNA hypermethylation
* GSTM1
* Gerotarget
* T cell differentiation
* aging
* epigenetic
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564710
}}