Редактирование: LGI3

Leucine-rich repeat LGI family member 3 precursor (LGI1-like protein 4) (Leucine-rich glioma-inactivated protein 3) [LGIL4] [UNQ8190/PRO23199]

==Publications==

{{medline-entry
|title=Immunohistochemical and biochemical analyses of [[LGI3]] in monkey brain: [[LGI3]] accumulates in aged monkey brains.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/17786549
|abstract=Leucine-rich glioma inactivated (LGI) 3 encodes a leucine-rich repeat protein. The precise function of [[LGI3]], however, remains unknown. We have previously shown that amyloid-beta peptide (Abeta) upregulates [[LGI3]] and that Abeta and [[LGI3]] colocalize on plasma membranes of cultured rat astrocytes. In the present study, we performed immunohistochemical and biochemical analyses of [[LGI3]] using various aged monkey brains. Immunohistochemistry showed that [[LGI3]] was present in almost all neural cells and mainly localized at plasma membranes and nuclei. In aged monkey brains, we found that [[LGI3]] accumulated on or near the plasma membranes of neurons, and colocalized with endocytosis-associated proteins and lipid raft markers. Double immunohistochemistry also showed that [[LGI3]] colocalized with Abeta in astrocytes of aged brains. Moreover, Western blot analyses revealed that [[LGI3]] may be cleaved in brain. Additionally, in aged monkeys [[LGI3]] accumulated in microsomal and nuclear brain fractions.
|mesh-terms=* Aging
* Animals
* Blotting, Western
* Brain
* Cell Nucleus
* Immunohistochemistry
* Macaca fascicularis
* Microsomes
* Models, Biological
* Protein Processing, Post-Translational
* Proteins

|full-text-url=https://sci-hub.do/10.1007/s10571-007-9205-6
}}