Редактирование: LAPTM4B

Lysosomal-associated transmembrane protein 4B (Lysosome-associated transmembrane protein 4-beta) [PSEC0001]

==Publications==

{{medline-entry
|title=Expression of 25 high egg production related transcripts that identified from hypothalamus and pituitary gland in red-feather Taiwan country chickens.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16919900
|abstract=Expression levels of 33 high egg production candidate transcripts in Red-feather Taiwan country chickens (TCCs) were examined by quantitative reverse-transcription (RT) polymerase chain reactions (PCR) in this study. Candidate transcripts were previously identified from a L2-B (L2-subtract-B) hypothalamus/pituitary gland subtractive cDNA library. In this subtractive cDNA library, two divergently selected strains of TCCs, B and L2 were used. These two strains were originated from one single population and were further subjected (since 1982) to the selections of body weight/comb size (B) and eggs to 40wk of age (L2), respectively. Hypothalamuses and pituitary glands that sampled from Red-feather TCCs were previously grouped into high (Red-high; n=20) and low (Red-low; n=20) egg productions based on the rate of lay after 1st egg (hen-day laying rate; %). Rates of lay after 1st egg (mean /-S.E.) in the Red-high and the Red-low subpopulations were 72.2 /-0.6 and 23.0 /-3.5, respectively (P<0.01). Quantitative RT-PCR validated that 25 candidate transcripts were significantly higher expressed in the Red-high than in the Red-low hens. These transcripts were [[ANP32A]], BDH, [[CDC42]], [[CNTN1]], [[COMT]], [[CPE]], [[CTNNB1]], [[DIO2]], [[EIF4E]], GARNL1, HSPCA, [[LAPTM4B]], [[MBP]], [[NAP1L4]], [[NCAM1]], [[PARK7]], PCDHA@, PGDS, [[PLAG1]], [[PRL]], [[RAD21]], [[SAR1A]], [[SCG2]], [[STMN1]] and [[UFM1]]. Among these transcripts, 15 (79.0%), 13 (68.4%), and 12 (63.2%) genes were annotated to involve in cellular physiological process (GO:0050875), metabolism (GO:0008152) and cell communication (GO:0007154). Identified transcripts that related to high egg production are most active in focal adhesion, adherens junction, MAPK signaling, tight junction and cell adhesion pathways.
|mesh-terms=* Aging
* Animals
* Chickens
* Color
* Feathers
* Female
* Gene Expression Profiling
* Gene Expression Regulation
* Hypothalamus
* Oviposition
* Pituitary Gland
* Taiwan
* Transcription, Genetic

|full-text-url=https://sci-hub.do/10.1016/j.anireprosci.2006.07.005
}}