Редактирование: KRR1

KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2) (KRR-R motif-containing protein 1) (Rev-interacting protein 1) (Rip-1) [HRB2]

==Publications==

{{medline-entry
|title=Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26416764
|abstract=Polycystic ovary syndrome (PCOS) is the most common reproductive disorder in women, yet there is little consensus regarding its aetiology. Here we perform a genome-wide association study of PCOS in up to 5,184 self-reported cases of White European ancestry and 82,759 controls, with follow-up in a further ∼2,000 clinically validated cases and ∼100,000 controls. We identify six signals for PCOS at genome-wide statistical significance (P<5 × 10(-8)), in/near genes ERBB4/HER4, [[YAP1]], [[THADA]], [[FSHB]], [[RAD50]] and [[KRR1]]. Variants in/near three of the four epidermal growth factor receptor genes (ERBB2/HER2, ERBB3/HER3 and ERBB4/HER4) are associated with PCOS at or near genome-wide significance. Mendelian randomization analyses indicate causal roles in PCOS aetiology for higher BMI (P=2.5 × 10(-9)), higher insulin resistance (P=6 × 10(-4)) and lower serum sex hormone binding globulin concentrations (P=5 × 10(-4)). Furthermore, genetic susceptibility to later menopause is associated with higher PCOS risk (P=1.6 × 10(-8)) and PCOS-susceptibility alleles are associated with higher serum anti-Müllerian hormone concentrations in girls (P=8.9 × 10(-5)). This large-scale study implicates an aetiological role of the epidermal growth factor receptors, infers causal mechanisms relevant to clinical management and prevention, and suggests balancing selection mechanisms involved in PCOS risk. 
|mesh-terms=* Acid Anhydride Hydrolases
* Adaptor Proteins, Signal Transducing
* Aging
* Case-Control Studies
* DNA Repair Enzymes
* DNA-Binding Proteins
* ErbB Receptors
* European Continental Ancestry Group
* Female
* Follicle Stimulating Hormone, beta Subunit
* Genome-Wide Association Study
* Humans
* Neoplasm Proteins
* Ovary
* Phosphoproteins
* Polycystic Ovary Syndrome
* Selection, Genetic
* Transcription Factors

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598835
}}