Редактирование: KLC1

Kinesin light chain 1 (KLC 1) [KLC] [KNS2]

==Publications==

{{medline-entry
|title=Variability in the kinesin light chain 1 gene may influence risk of age-related cataract.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/17653041
|abstract=Kinesin-mediated cargo vesicle transport is fundamental to the maintenance of a proper lens fiber structure, which is essential for the transparency of the lens. Here, we test the hypothesis that the rs8702 polymorphism in the kinesin light chain 1 gene ([[KLC1]]), previously linked to Alzheimer disease (AD), may play a role in cataractogenesis. Patients with nuclear (n=76), cortical (n=154), posterior subcapsular (n=117), and mixed (n=148) cataract as well as 183 controls were analyzed for the [[KLC1]] rs8702 polymorphism using the dynamic allele-specific hybridization (DASH) technique. The GG genotype of rs8702 was significantly over-represented among cataract patients as compared to controls (63% versus 52%, respectively, p=0.008) and associated with an age-adjusted odds ratio for cataract development of 1.61 (95% confidence interval 1.12-2.31). This association was not confined to any particular cataract type. The [[KLC1]] gene may be a novel susceptibility gene for age-related cataract.
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Alleles
* Cataract
* Female
* Gene Frequency
* Genetic Predisposition to Disease
* Genotype
* Humans
* Logistic Models
* Male
* Microtubule-Associated Proteins
* Middle Aged
* Nucleic Acid Hybridization
* Odds Ratio
* Polymorphism, Genetic
* Smoking

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776535
}}