Редактирование: KIAA0319

Dyslexia-associated protein KIAA0319 precursor

==Publications==

{{medline-entry
|title=The Dyslexia-susceptibility Protein [[KIAA0319]] Inhibits Axon Growth Through Smad2 Signaling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28334068
|abstract=[[KIAA0319]] is a transmembrane protein associated with dyslexia with a presumed role in neuronal migration. Here we show that [[KIAA0319]] expression is not restricted to the brain but also occurs in sensory and spinal cord neurons, increasing from early postnatal stages to adulthood and being downregulated by injury. This suggested that [[KIAA0319]] participates in functions unrelated to neuronal migration. Supporting this hypothesis, overexpression of [[KIAA0319]] repressed axon growth in hippocampal and dorsal root ganglia neurons; the intracellular domain of [[KIAA0319]] was sufficient to elicit this effect. A similar inhibitory effect was observed in vivo as axon regeneration was impaired after transduction of sensory neurons with [[KIAA0319]]. Conversely, the deletion of Kiaa0319 in neurons increased neurite outgrowth in vitro and improved axon regeneration in vivo. At the mechanistic level, [[KIAA0319]] engaged the [[JAK2]]-[[SH2B1]] pathway to activate Smad2, which played a central role in [[KIAA0319]]-mediated repression of axon growth. In summary, we establish [[KIAA0319]] as a novel player in axon growth and regeneration with the ability to repress the intrinsic growth potential of axons. This study describes a novel regulatory mechanism operating during peripheral nervous system and central nervous system axon growth, and offers novel targets for the development of effective therapies to promote axon regeneration.
|mesh-terms=* Aging
* Animals
* Axons
* Cell Adhesion Molecules
* Cell Enlargement
* Cell Line
* Cells, Cultured
* Female
* Ganglia, Spinal
* Hippocampus
* Humans
* Janus Kinase 2
* Male
* Mice, Inbred C57BL
* Mice, Transgenic
* Nerve Regeneration
* Nerve Tissue Proteins
* Neuronal Outgrowth
* Neurons
* Protein Domains
* Rats, Wistar
* Sciatic Nerve
* Smad2 Protein
* Spinal Cord
|keywords=* KIAA0319
* Smad2
* axon growth
* axon regeneration
* dyslexia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905272
}}