Редактирование: IQGAP2

Ras GTPase-activating-like protein IQGAP2

==Publications==

{{medline-entry
|title=Development of hepatocellular carcinoma in Iqgap2-deficient mice is [[IQGAP1]] dependent.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/18180285
|abstract=IQGAPs are multidomain scaffolding proteins that integrate Rho GTPase and Ca2 /calmodulin signals with cell adhesive and cytoskeletal reorganizational events. Targeted disruption of the murine Iqgap2 gene resulted in the age-dependent development of apoptosis and hepatocellular carcinoma (HCC), characterized by the overexpression of [[IQGAP1]], the loss of membrane E-cadherin expression, the cytoplasmic translocation (and activation) of beta-catenin, and the overexpression of a nuclear target of beta-catenin, cyclin D1. In normal hepatocytes, [[IQGAP2]] was found to exist as one component of a multifunctional scaffolding complex comprising [[IQGAP1]], beta-catenin, and E-cadherin, with no evidence for direct [[IQGAP1]]-[[IQGAP2]] interactions. Interbreeding of Iqgap2(-/-) mice into the Iqgap1(-/-) background resulted in the phenotypic correction of the preexisting hepatopathy, decreases in the incidence and sizes of HCC tumors, and the normalization of overall survival rates compared to those of Iqgap2(-/-) mice, suggesting that maximal penetrance of the Iqgap2(-/-) HCC phenotype requires the coordinate expression of [[IQGAP1]]. These results identify Iqgap2 as a novel tumor suppressor gene specifically linked to the development of HCC and the activation of the Wnt/beta-catenin signaling pathway, while also suggesting that [[IQGAP1]] and [[IQGAP2]] retain functionally divergent roles in hepatocellular carcinogenesis.
|mesh-terms=* Aging
* Alkaline Phosphatase
* Alleles
* Animals
* Apoptosis
* Bilirubin
* Carcinoma, Hepatocellular
* Crosses, Genetic
* Electroporation
* Embryonic Stem Cells
* Liver
* Liver Neoplasms
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Mitochondria, Liver
* Muscle, Skeletal
* Penetrance
* Reverse Transcriptase Polymerase Chain Reaction
* Tumor Suppressor Proteins
* ras GTPase-Activating Proteins

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258764
}}