Редактирование: GPR139

Probable G-protein coupled receptor 139 (G(q)-coupled orphan receptor GPRg1) (G-protein-coupled receptor PGR3) [GPRG1] [PGR3]

==Publications==

{{medline-entry
|title=Characterisation and differential expression of two very closely related G-protein-coupled receptors, [[GPR139]] and [[GPR142]], in mouse tissue and during mouse development.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16378626
|abstract=By searching the human and mouse genomic databases we found two G-protein-coupled receptors, [[GPR139]] and [[GPR142]], with characteristic motifs of the rhodopsin family of receptors. The gene for [[GPR139]] maps to chromosome 7F1 of mouse and 16p12.3 of human and that for [[GPR142]] to 11E2 of mouse and 17q25.1 of human. We isolated [[GPR139]] from a cDNA library of adult mouse brain and [[GPR142]] from a cDNA library of brains from 15-day-old mouse embryos. [[GPR139]] mRNA was predominantly expressed in specific areas of human and mouse brains, whereas [[GPR142]] mRNA showed a more ubiquitous expression both in the brain and in various peripheral glands and organs. A 50% identity and a 67% homology at the amino-acid level between the two receptors and only 20-25% identity with other G-protein-coupled receptors established them as a new subbranch within the phylogenetic tree and hints at a common or similar ligand(s). Preliminary results suggest that the cognate ligand is present in brain extracts and is, most likely, a small peptide. [[GPR139]] signal transduction in Chinese hamster ovary cells requires coupling to an inhibitory G-protein and is mediated by phospholipase C. Dimer formation may be necessary for proper function.
|mesh-terms=* Aging
* Amino Acid Sequence
* Animals
* Brain
* Cloning, Molecular
* Conserved Sequence
* Embryonic Development
* Gene Expression Regulation, Developmental
* Humans
* Mice
* Molecular Sequence Data
* Nerve Tissue Proteins
* Organ Specificity
* RNA, Messenger
* Receptors, G-Protein-Coupled
* Recombinant Proteins
* Sequence Alignment
* Sequence Homology, Amino Acid

|full-text-url=https://sci-hub.do/10.1016/j.neuropharm.2005.11.003
}}