Редактирование: GDF7

Growth/differentiation factor 7 precursor (GDF-7)

==Publications==

{{medline-entry
|title=Growth/differentiation factor 7 is preferentially expressed in the primary motor area of the monkey neocortex.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/11238730
|abstract=We applied a differential display PCR technique to isolate molecules that are area-specific in expression in the primate neocortex, and found that growth/differentiation factor 7 ([[GDF7]]), a member of the bone morphogenetic protein (BMP)/transforming growth factor (TGF) beta super-family, is preferentially expressed in the primary motor area of African green monkeys (Cercopithecus aethiops). We proved that [[GDF7]] is 10 times more abundant in the motor cortex than in the visual cortex by northern blotting and quantitative RT-PCR. When we examined the neocortex of closely related rhesus monkeys (Macaca mulatta), [[GDF7]] was also most abundant in the motor cortex, although the regional difference was reduced to 3-fold. This differential expression pattern was observed in both newborn and infant rhesus monkeys. We found that several type I/II receptors of BMP, candidates of the receptors for [[GDF7]], are uniformly expressed in the mature neocortex. The unique expression pattern of [[GDF7]] suggests that it may play an active role in the motor area of the primate neocortex.
|mesh-terms=* Aging
* Amino Acid Sequence
* Animals
* Animals, Newborn
* Bone Morphogenetic Proteins
* Chlorocebus aethiops
* Gene Expression Regulation, Developmental
* Gene Library
* Growth Substances
* Macaca fascicularis
* Macaca mulatta
* Molecular Sequence Data
* Motor Cortex
* Neocortex
* Organ Specificity
* Polymerase Chain Reaction
* RNA, Messenger
* Recombinant Proteins
* Sequence Alignment
* Sequence Homology, Amino Acid
* Transcription, Genetic
* Transfection

|full-text-url=https://sci-hub.do/10.1046/j.1471-4159.2001.00177.x
}}