Редактирование: GABRA2

Gamma-aminobutyric acid receptor subunit alpha-2 precursor (GABA(A) receptor subunit alpha-2)

==Publications==

{{medline-entry
|title=The role of [[GABRA2]] in risk for conduct disorder and alcohol and drug dependence across developmental stages.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16557364
|abstract=We use findings from the behavior genetics literature about how genetic factors (latently) influence alcohol dependence and related disorders to develop and test hypotheses about the risk associated with a specific gene, [[GABRA2]], across different developmental stages. This gene has previously been associated with adult alcohol dependence in the Collaborative Study of the Genetics of Alcoholism (COGA) sample [Edenberg, H. J., Dick, D. M., Xuei, X., Tian, H., Almasy, L., Bauer, L. O., Crowe, R., Goate, A., Hesselbrock, V., Jones, K. A., Kwon, J., Li, T. K., Nurnberger Jr., J. I., O'Connor, S. J., Reich, T., Rice, J., Schuckit, M., Porjesz, B., Foroud, T., and Begleiter, H. (2004). Am. J. Hum. Genet. 74:705-714] and other studies [Covault, J., Gelernter, J., Hesselbrock, V., Nellissery, M., and Kranzler, H. R. (2004). Am. J. Med. Genet. B Neuropsychiatr. Genet. 129B:104-109; Lappalainen, J., Krupitsky, E., Remizov, M., Pchelina, S., Taraskina, A., Zvartau, E., Somberg, L. K., Covault, J., Kranzler, H. R., Krystal, J., and Gelernter, J. (2005). Alcohol. Clin. Exp. Res. 29:493-498]. In a sample of children and adolescents ascertained as part of the COGA project, we find that [[GABRA2]] is significantly associated with childhood conduct disorder symptoms, but not with childhood alcohol dependence symptoms. A consistent elevation in risk for alcohol dependence associated with [[GABRA2]] is not evident until the mid-20s and then remains throughout adulthood. [[GABRA2]] is also associated with other drug dependence in our sample, both in adolescence and adulthood.
|mesh-terms=* Adolescent
* Adult
* Age of Onset
* Aging
* Alcoholism
* Child
* Humans
* Mental Disorders
* Middle Aged
* Receptors, GABA-A
* Regression Analysis
* Risk Factors
* Substance-Related Disorders
* Survival Analysis
* United States

|full-text-url=https://sci-hub.do/10.1007/s10519-005-9041-8
}}