Редактирование: FXYD5

FXYD domain-containing ion transport regulator 5 precursor (Dysadherin) [DYSAD] [IWU1] [HSPC113] [UNQ2561/PRO6241]

==Publications==

{{medline-entry
|title=Reduced expression of FXYD domain containing ion transport regulator             5 in association with hypertension.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22085977
|abstract=Experimental evidence indicates that hypertension is a multifactorial disorder and that the products of several genes may contribute to its development. The aim of this study was to investigate the expression of hypertension-related genes in spontaneous hypertensive rats (SHRs). A microarray screening for hypertension-related genes was conducted in SHRs and Wistar-Kyoto (WKY) rats using total-RNA extracted from second-order mesenteric arteries and kidneys. The [[FXYD5]] mRNA expression in vascular smooth muscle cells (VSMCs) was silenced by RNA interference (RNAi). Meanwhile, the [[FXYD5]] mRNA overexpression in renal tubular epithelial cells (RTECs) was induced by the recombinant plasmid pcDNA3.1( )-[[FXYD5]]. The expression of [[FXYD5]] mRNA was found to be 14.8-fold lower in SHR rats compared to that in WKY rats (P<0.01). The levels of [[FXYD5]] mRNA expression were the highest in kidneys of SHR 13-week-old rats when the blood pressure reached the highest levels. The down-regulated [[FXYD5]] mRNA expression inhibited the migration of smooth muscle cells (P<0.01) and cell membrane Na⁺-K⁺-ATPase activity (P<0.01). Up-regulated [[FXYD5]] mRNA expression enhanced the renal tubular epithelial cell membrane Na⁺-K⁺-ATPase activity (P<0.05) and cell proliferation (P<0.05). [[FXYD5]] is related to the migration of smooth muscle cells and cell membrane Na⁺-K⁺-ATPase activity in rodents. The results of the present study suggest that [[FXYD5]] may have profound impact on the regulation of blood pressure, and that this gene may be a potential target for anti-hypertensive therapy.
|mesh-terms=* Aging
* Animals
* Cell Line
* Cell Movement
* Cell Proliferation
* Gene Expression Profiling
* Gene Expression Regulation
* Genetic Vectors
* Hypertension
* Male
* Membrane Glycoproteins
* Membrane Proteins
* Muscle, Smooth, Vascular
* Myocytes, Smooth Muscle
* RNA, Messenger
* Rats
* Rats, Inbred SHR
* Rats, Inbred WKY
* Sodium-Potassium-Exchanging ATPase
* Transfection

|full-text-url=https://sci-hub.do/10.3892/ijmm.2011.837
}}