Редактирование: FGF20

Fibroblast growth factor 20 (FGF-20)

==Publications==

{{medline-entry
|title=Genetic variation in [[FGF20]] modulates hippocampal biology.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/20427658
|abstract=We explored the effect of single-nucleotide polymorphisms (SNPs) in the fibroblast growth factor 20 gene ([[FGF20]]) associated with risk for Parkinson's disease on brain structure and function in a large sample of healthy young-adult human subjects and also in elderly subjects to look at the interaction between genetic variations and age (N = 237; 116 men; 18-87 years). We analyzed high-resolution anatomical magnetic resonance images using voxel-based morphometry, a quantitative neuroanatomical technique. We also measured [[FGF20]] mRNA expression in postmortem human brain tissue to determine the molecular correlates of these SNPs (N = 108; 72 men; 18-74 years). We found that the T allele carriers of rs12720208 in the 3'-untranslated region had relatively larger hippocampal volume (p = 0.0059) and diminished verbal episodic memory (p = 0.048) and showed steeper decreases of hippocampal volume with normal aging (p = 0.026). In postmortem brain, T allele carriers had greater expression of hippocampal [[FGF20]] mRNA (p = 0.037), consistent with a previously characterized microRNA mechanism. The C allele matches a predicted miR-433 microRNA binding domain, whereas the T allele disrupts it, resulting in higher [[FGF20]] protein translation. The strong [[FGF20]] genetic effects in hippocampus are presumably mediated by activation of the [[FGFR1]] (FGF receptor 1), which is expressed in mammalian brain most abundantly in the hippocampus. These associations, from mRNA expression to brain morphology to cognition and an interaction with aging, confirm a role of [[FGF20]] in human brain structure and function during development and aging.
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Alleles
* Cognition
* Female
* Fibroblast Growth Factors
* Genotype
* Hippocampus
* Humans
* Male
* MicroRNAs
* Middle Aged
* Organ Size
* Polymorphism, Single Nucleotide
* RNA, Messenger
* Receptor, Fibroblast Growth Factor, Type 1
* Young Adult

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909689
}}