Редактирование: FGF14

Fibroblast growth factor 14 (FGF-14) (Fibroblast growth factor homologous factor 4) (FHF-4) [FHF4]

==Publications==

{{medline-entry
|title=Fibroblast Growth Factor 14 Modulates the Neurogenesis of Granule Neurons in the Adult Dentate Gyrus.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26687232
|abstract=Adult neurogenesis, the production of mature neurons from progenitor cells in the adult mammalian brain, is linked to the etiology of neurodegenerative and psychiatric disorders. However, a thorough understanding of the molecular elements at the base of adult neurogenesis remains elusive. Here, we provide evidence for a previously undescribed function of fibroblast growth factor 14 ([[FGF14]]), a brain disease-associated factor that controls neuronal excitability and synaptic plasticity, in regulating adult neurogenesis in the dentate gyrus (DG). We found that [[FGF14]] is dynamically expressed in restricted subtypes of sex determining region Y-box 2 (Sox2)-positive and doublecortin ([[DCX]])-positive neural progenitors in the DG. Bromodeoxyuridine (BrdU) incorporation studies and confocal imaging revealed that genetic deletion of Fgf14 in Fgf14   mice leads to a significant change in the proportion of proliferating and immature and mature newly born adult granule cells. This results in an increase in the late immature and early mature population of [[DCX]] and calretinin (CR)-positive neurons. Electrophysiological extracellular field recordings showed reduced minimal threshold response and impaired paired-pulse facilitation at the perforant path to DG inputs in Fgf14   compared to Fgf14   mice, supporting disrupted synaptic connectivity as a correlative read-out to impaired neurogenesis. These new insights into the biology of [[FGF14]] in neurogenesis shed light into the signaling pathways associated with disrupted functions in complex brain diseases.
|mesh-terms=* Aging
* Animals
* Animals, Newborn
* Apoptosis
* Cell Count
* Cell Differentiation
* Cell Survival
* Cytoplasmic Granules
* Dentate Gyrus
* Female
* Fibroblast Growth Factors
* Gene Deletion
* Gene Expression Profiling
* Male
* Mice, Inbred C57BL
* Microtubule-Associated Proteins
* Neural Stem Cells
* Neurogenesis
* Neurons
* Neuropeptides
* Synapses
|keywords=* Adult neurogenesis
* Ataxia
* Axon initial segment
* FGF14
* Growth factors
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916041
}}