Редактирование: EXT1

Exostosin-1 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 1) (Putative tumor suppressor protein EXT1)

==Publications==

{{medline-entry
|title=Gene expression of [[EXT1]] and [[EXT2]] during mouse brain development.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/12644256
|abstract=Heparan sulfate (HS) and heparan sulfate proteoglycans (HSPGs) play significant roles in various biological processes. There is a wealth of circumstantial and experimental evidence suggesting the roles of HS in mammalian neural development. HS synthesis is governed by a series of enzymes. Among them, two enzymes, [[EXT1]] and [[EXT2]], catalyze polymerization of glucuronic acid and N-acetylglucosamine, the crucial step of HS synthesis. To obtain insight into the roles of HS in neural development, we examined the spatiotemporal expression patterns of [[EXT1]] and [[EXT2]] during mice brain development. RT-PCR analyses showed that expression of [[EXT1]] and [[EXT2]] peaks during early postnatal period in the cerebrum and around birth in the cerebellum. In situ hybridization revealed that in the embryonic brain, [[EXT1]] and [[EXT2]] were localized primarily in the neuroepithelial cells surrounding the lateral ventricles, the mesencephalic vesicle, and the fourth ventricle. In the early postnatal stage, intense expression of [[EXT1]] and [[EXT2]] was observed in the cerebral cortex and the hippocampus formation. In the postnatal cerebellum, expression of [[EXT1]] and [[EXT2]] was mainly observed in external and internal granular layers. Our results demonstrate that [[EXT1]] and [[EXT2]] are highly expressed in the developing brain, and that their expression is developmentally regulated, suggesting that HS is involved in various neurodevelopmental processes.
|mesh-terms=* Aging
* Animals
* Animals, Newborn
* Brain
* Cell Differentiation
* Cerebellum
* Fetus
* Gene Expression Regulation, Developmental
* Gene Expression Regulation, Enzymologic
* Heparitin Sulfate
* Hippocampus
* Lateral Ventricles
* Mice
* Mice, Inbred C57BL
* N-Acetylglucosaminyltransferases
* Neurons
* RNA, Messenger
* Stem Cells
* Telencephalon

|full-text-url=https://sci-hub.do/10.1016/s0165-3806(03)00010-5
}}