Редактирование: ESAM

Endothelial cell-selective adhesion molecule precursor [UNQ220/PRO246]

==Publications==

{{medline-entry
|title=The endothelial antigen [[ESAM]] marks primitive hematopoietic progenitors throughout life in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/19096010
|abstract=Although recent advances have enabled hematopoietic stem cells (HSCs) to be enriched to near purity, more information about their characteristics will improve our understanding of their development and stage-related functions. Here, using microarray technology, we identified endothelial cell-selective adhesion molecule ([[ESAM]]) as a novel marker for murine HSCs in fetal liver. Esam was expressed at high levels within a Rag1(-) c-kit(Hi) Sca1( ) HSC-enriched fraction, but sharply down-regulated with activation of the Rag1 locus, a valid marker for the most primitive lymphoid progenitors in E14.5 liver. The HSC-enriched fraction could be subdivided into 2 on the basis of [[ESAM]] levels. Among endothelial antigens on hematopoietic progenitors, [[ESAM]] expression showed intimate correlation with HSC activity. The [[ESAM]](Hi) population was highly enriched for multipotent myeloid-erythroid progenitors and primitive progenitors with lymphopoietic activity, and exclusively reconstituted long-term lymphohematopoiesis in lethally irradiated recipients. Tie2( ) c-kit( ) lymphohematopoietic cells in the E9.5-10.5 aorta-gonad-mesonephros region also expressed high levels of [[ESAM]]. Furthermore, [[ESAM]] was detected on primitive hematopoietic progenitors in adult bone marrow. Interestingly, [[ESAM]] expression in the HSC-enriched fraction was up-regulated in aged mice. We conclude that [[ESAM]] marks HSC in murine fetal liver and will facilitate studies of hematopoiesis throughout life.
|mesh-terms=* Aging
* Animals
* Biomarkers
* Cell Adhesion Molecules
* Cells, Cultured
* Embryo, Mammalian
* Endothelial Cells
* Female
* Fetus
* Gene Expression Profiling
* Gene Expression Regulation, Developmental
* Gene Knock-In Techniques
* Hematopoiesis
* Hematopoietic Stem Cells
* Liver
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Oligonucleotide Array Sequence Analysis

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974489
}}