Редактирование: EFCAB5

calcium-binding domain-containing protein 5

==Publications==

{{medline-entry
|title=Genetic architecture of epigenetic and neuronal ageing rates in human brain regions.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28516910
|abstract=Identifying genes regulating the pace of epigenetic ageing represents a new frontier in genome-wide association studies (GWASs). Here using 1,796 brain samples from 1,163 individuals, we carry out a GWAS of two DNA methylation-based biomarkers of brain age: the epigenetic ageing rate and estimated proportion of neurons. Locus 17q11.2 is significantly associated (P=4.5 × 10 ) with the ageing rate across five brain regions and harbours a cis-expression quantitative trait locus for [[EFCAB5]] (P=3.4 × 10 ). Locus 1p36.12 is significantly associated (P=2.2 × 10 ) with epigenetic ageing of the prefrontal cortex, independent of the proportion of neurons. Our GWAS of the proportion of neurons identified two genome-wide significant loci (10q26 and 12p13.31) and resulted in a gene set that overlaps significantly with sets found by GWAS of age-related macular degeneration (P=1.4 × 10 ), ulcerative colitis (P<1.0 × 10 ), type 2 diabetes (P=2.8 × 10 ), hip/waist circumference in men (P=1.1 × 10 ), schizophrenia (P=1.6 × 10 ), cognitive decline (P=5.3 × 10 ) and Parkinson's disease (P=8.6 × 10 ).
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Brain
* Brain Mapping
* Calcium-Binding Proteins
* Child
* Child, Preschool
* Cognitive Dysfunction
* DNA Methylation
* Epigenesis, Genetic
* Female
* Genome, Human
* Genome-Wide Association Study
* Humans
* Infant
* Male
* Middle Aged
* Nerve Tissue Proteins
* Neurodegenerative Diseases
* Neurons
* Quantitative Trait Loci

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454371
}}