Редактирование: DNMBP

Dynamin-binding protein (Scaffold protein Tuba) [ARHGEF36] [KIAA1010] [TUBA]

==Publications==

{{medline-entry
|title=Dynamin binding protein gene expression and memory performance in aged rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21232816
|abstract=Previous studies have shown that messenger RNA (mRNA) of the dynamin-binding protein ([[DNMBP]]), a scaffold protein regulating actin cytoskeleton and synaptic vesicle pools, is lower in neuropathologically-confirmed Alzheimer's brains. Here we investigated whether a deficit in long term memory formation during physiological aging is also associated with lower [[DNMBP]] expression. Hippocampal [[DNMBP]] mRNA was quantified by quantitative real time reverse transcriptase polymerase chain reaction (qRT-PCR) following inhibitory avoidance task in aged (26- to 27-month-old) rats that, according to memory performance, were ranked as good responders (GR) and bad responders (BR), in adult (3-month-old), late-adult (19-month-old), and aged (26-27-month-old) naive animals. We found that [[DNMBP]] mRNA levels were significantly higher in naive adults versus late adult and aged naive rats, in GR versus BR, and in pooled GR and BR versus aged-matched controls. Our data provide the first evidence that hippocampal [[DNMBP]] mRNA expression is reduced during physiological aging, and suggest that the capability to increase the expression of this mRNA may be a requirement for preserving long term memory formation during aging.
|mesh-terms=* Aging
* Animals
* Avoidance Learning
* Carrier Proteins
* Cytoskeletal Proteins
* Down-Regulation
* Female
* Gene Expression Regulation
* Hippocampus
* Memory, Long-Term
* Protein Binding
* Rats
* Rats, Wistar
* Real-Time Polymerase Chain Reaction

|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2010.11.012
}}