Редактирование: DNAJB9

DnaJ homolog subfamily B member 9 precursor (Endoplasmic reticulum DNA J domain-containing protein 4) (ER-resident protein ERdj4) (ERdj4) (Microvascular endothelial differentiation gene 1 protein) (Mdg-1) [MDG1] [UNQ743/PRO1471]

==Publications==

{{medline-entry
|title=[[DNAJB9]] Inhibits p53-Dependent Oncogene-Induced Senescence and Induces Cell Transformation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32264658
|abstract=[i][[DNAJB9]][/i] is known to be a member of the molecular chaperone gene family, whose cellular function has not yet been fully characterized. Here, we investigated the cellular function of [[DNAJB9]] under strong mitogenic signals. We found that [[DNAJB9]] inhibits p53-dependent oncogene-induced senescence (OIS) and induces neoplastic transformation under oncogenic RAS activation in mouse primary fibroblasts. In addition, we observed that [[DNAJB9]] interacts physically with p53 under oncogenic RAS activation and that the p53-interacting region of [[DNAJB9]] is critical for the inhibition of p53-dependent OIS and induction of neoplastic transformation by [[DNAJB9]]. These results suggest that [[DNAJB9]] induces cell transformation under strong mitogenic signals, which is attributable to the inhibition of p53-dependent OIS by physical interactions with p53. This study might contribute to our understanding of the cellular function of [[DNAJB9]] and the molecular basis of cell transformation.

|keywords=* DNAJB9
* RAS
* p53
* senescence
* transformation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191047
}}