Редактирование: CRHBP

Corticotropin-releasing factor-binding protein precursor (CRF-BP) (CRF-binding protein) (Corticotropin-releasing hormone-binding protein) (CRH-BP) [CRFBP]

==Publications==

{{medline-entry
|title=Aging-related changes in cutaneous corticotropin-releasing hormone system reflect a defective neuroendocrine-stress response in aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22533365
|abstract=Skin, being a mirror of the body, is a major target for aging research. Aging is a complex process that involves the decline of function or dysfunction of many systems. The corticotropin-releasing hormone ([[CRH]]) system is involved in skin inflammation. In addition, [[CRH]] has a suggested role in age-associated conditions and in animal aging models. However, a consistent logic interaction between the different [[CRH]] system components and the aging process has, to our knowledge, never been examined before. The expression of [[CRH]], [[CRH]]-binding protein ([[[[CRH]]BP]]), [[CRH]] receptor 1 ([[CRH]]R1), and [[CRH]] receptor 2 ([[[[CRH]]R2]]) in healthy skin samples of 42 patients of different ages (18-92 years) was evaluated by immunohistochemistry, and the age-related changes were assessed. Compared with young skin, the aged skin displayed an upregulation of [[CRH]] in sebaceous glands and [[CRH]]R1 in hair follicles and the epidermis. Moreover, age-associated downregulation of [[[[CRH]]BP]] in the sebaceous and sweat glands was detected, whereas the [[[[CRH]]R2]] showed no age-related changes. Our findings suggest that the age-associated changes in the expression of [[CRH]] system components reflect an exaggerated stress response reaction, putting the aged skin continuously in a stress-like situation.
|mesh-terms=* Adult
* Aged
* Aging
* Carrier Proteins
* Corticotropin-Releasing Hormone
* Female
* Humans
* Male
* Middle Aged
* Receptors, Corticotropin-Releasing Hormone
* Sebaceous Glands
* Skin
* Stress, Physiological
* Young Adult

|full-text-url=https://sci-hub.do/10.1089/rej.2011.1294
}}