Редактирование: COL4A6

Collagen alpha-6(IV) chain precursor

==Publications==

{{medline-entry
|title=Tissue- and developmental stage-specific activation of alpha 5 and alpha 6(IV) collagen expression in the upper gastrointestinal tract of transgenic mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/14592452
|abstract=Little is known about mechanisms regulating gene expression for the alpha chains of basement membrane type IV collagen, arranged head-to-head in transcription units [[COL4A1]]-[[COL4A2]], [[COL4A3]]-[[COL4A4]], and [[COL4A5]]-[[COL4A6]], and implicated broadly in genetic diseases. To investigate these mechanisms, we generated transgenic mouse lines bearing 5'-flanking sequences of [[COL4A5]] and [[COL4A6]], cloned upstream of a lacZ reporter gene. A 3.8-kb fragment upstream of [[COL4A6]] directs reporter gene expression in the esophagus, stomach, and duodenum, whereas a 13.8-kb fragment directs expression in the esophagus only. A 10.6-kb fragment upstream of [[COL4A5]] directs expression in the esophagus. Coupled with evidence of long-range conservation between human and mouse non-coding sequences, described herein, our findings provide the first indication that highly specialized patterns characteristic of [[COL4A5]]-[[COL4A6]] expression in vivo arise from effects of distributed cis-acting regulatory elements on a bidirectional proximal promoter, itself transcriptionally competent.
|mesh-terms=* Aging
* Amino Acid Sequence
* Animals
* Collagen Type IV
* Gene Expression Regulation
* Genes, Regulator
* Humans
* Mice
* Mice, Transgenic
* Molecular Sequence Data
* Organ Specificity
* Protein Subunits
* Sequence Homology
* Species Specificity
* Tissue Distribution
* Transcriptional Activation
* Upper Gastrointestinal Tract

|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2003.09.233
}}