Редактирование: BLNK

B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65) [BASH] [SLP65]

==Publications==

{{medline-entry
|title=Requirement for B cell linker protein ([[BLNK]]) in B cell development.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/10583957
|abstract=Linker proteins function as molecular scaffolds to localize enzymes with substrates. In B cells, B cell linker protein ([[BLNK]]) links the B cell receptor ([[BCR]])-activated Syk kinase to the phosphoinositide and mitogen-activated kinase pathways. To examine the in vivo role of [[BLNK]], mice deficient in [[BLNK]] were generated. B cell development in [[BLNK]]-/- mice was blocked at the transition from B220 CD43  progenitor B to B220 CD43- precursor B cells. Only a small percentage of immunoglobulin M   (IgM  ), but not mature IgMloIgDhi, B cells were detected in the periphery. Hence, [[BLNK]] is an essential component of [[BCR]] signaling pathways and is required to promote B cell development.
|mesh-terms=* Adaptor Proteins, Signal Transducing
* Aging
* Animals
* B-Lymphocyte Subsets
* B-Lymphocytes
* Bone Marrow Cells
* Carrier Proteins
* Cell Count
* Cell Differentiation
* Cell Separation
* Cell Size
* Flow Cytometry
* Gene Targeting
* Hematopoietic Stem Cells
* Immunoglobulin M
* Leukopoiesis
* Lymphoid Tissue
* Mice
* Mice, Inbred C57BL
* Phosphoproteins
* Receptors, Antigen, B-Cell
* Second Messenger Systems
* Signal Transduction

|full-text-url=https://sci-hub.do/10.1126/science.286.5446.1949
}}