Редактирование: BAG1

BAG family molecular chaperone regulator 1 (BAG-1) (Bcl-2-associated athanogene 1) [HAP]

==Publications==

{{medline-entry
|title=[[BAG3]] and friends: co-chaperones in selective autophagy during aging and disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21681022
|abstract=There is a reciprocal change in the expression of two members of the BAG (Bcl-2-associated athanogen) family, [[BAG1]] and [[BAG3]], during cellular aging and under acute stress ("[[BAG1]]-[[BAG3]]-switch"). [[BAG3]] was recently described as a mediator of a novel macroautophagy pathway that uses the specificity of heat shock protein 70 (HSP70) to misfolded proteins and also involves other protein partners, such as [[HSPB8]]. Also crucial for induction and execution of autophagy are sequestosome-1/p62 (SQSTM1/p62) and LC3, an autophagosome-associated protein. In this novel pathway, [[BAG3]] mediates the targeting and transport of degradation-prone substrates into aggresomes via the microtubule-motor dynein. Interestingly, aggresome-targeting by [[BAG3]] does not depend on substrate ubiquitination and is, therefore, involved in the clearance of misfolded proteins that are not ubiquitinated.
|mesh-terms=* Adaptation, Physiological
* Adaptor Proteins, Signal Transducing
* Aging
* Animals
* Autophagy
* DNA-Binding Proteins
* Disease
* Dyneins
* Models, Biological
* Molecular Chaperones
* Proteasome Endopeptidase Complex
* Transcription Factors
* Ubiquitination

|full-text-url=https://sci-hub.do/10.4161/auto.7.7.15844
}}